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@BiancaSylvester
Flag of Romania Brasov, Romania
Member since September 15, 2017
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BiancaSylvester

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* Who am I? I am an experienced scientific writer and editor, and my goal is to make writing, proofreading, and editing projects be effective and yet hassle free for my clients. I hold a PhD in Pharmaceutical Sciences, specializing in pharmaceutical development and biopharmaceutics. Moreover, my experience as Editor for MDPI, an academic open-access publisher, provides me with the right expertise when it comes to getting your work published. * What do I do? I specialize in providing writing, editing, proofreading and communications solutions for scientists. Whether you are in the pharmaceutical, medical or life sciences-related sector, I can help you move your research forward. My work also extends to school projects, research proposals and blog posts. * What value can I bring to your work? - Reduced time from draft to publication - Improved chances of acceptance - Get the attention you deserve - A second set of independent eyes - A good balance between time, quality and money
$3 USD/hr
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Experience

Section Managing Editor for the Journals Viruses and Reproductive Medicine (MDPI)

Oct 2016

-check the suitability of submitted manuscripts, check into the peer-review, decision and editing records to all manuscripts have been peer-reviewed and processed correctly. -organize the Editorial Board and find suitable candidates for the Editor-in-Chief position -report the weekly progress and news about the journal to the Editor-in-Chief -setup special issues for the journal Viruses and Reproductive Medicine -update the MDPI blog- Insights into Open Access Publishing

Scientific Research Assistant

Jan 2016 - May 2017 (1 year)

Project name: „Co-encapsulated doxorubicin and curcumin long circulating nanoformulations towards increased efficiency of colon cancer therapy" ▪ Pre-formulation studies, optimization of the manufacturing process of the liposomes for efficient codelivery of doxorubicin and curcumin by means of Design of Experiments (DoE) ▪ Development of HPLC-FLD/UV methods for accurate and simultaneous determination of the active principle ingredients

Scientific Research Assistant

Jan 2016 - May 2017 (1 year)

Project name: "Quality by Design approach and development of Process Analytical Technology for a matrix type sustained–release product" -[login to view URL] ▪ Development of the manufacturing process of a matrix type sustained–release product by means of Quality by Design (QbD) approach ▪ Development, validation and implementation of in-line monitoring techniques of the manufacturing process

Education

PhD- Pharmaceutical Sciences

2013 - 2017 (4 years)

PhD training

2014 - 2015 (1 year)

Publications

Form. Opt. of Freeze-Dried LCL and In-Line Monit. of the Freeze-Drying Process using an NIRs

ttp://[login to view URL](17)30381-7/pdf The effect of lyoprotectant type and concentration on the stability of freeze-dried prednisolone sodium phosphate-loaded long-circulating liposomes (LCL-PLP) was investigated. Further on, the study demonstrated the possibility of NIR spectroscopy to provide valuable insights for detecting critical changes in acyl chain packing of the liposome bilayer.

Optimization of Prednisolone- loaded LCL via Application of Quality by Design (QbD) Approach

[login to view URL] Quality by design principles (QbD) were used to assist the formulation of prednisolone-loaded long-circulating liposomes (LCL-PLP) in order to gain a more comprehensive understanding of the preparation process. This approach enables us to improve the final product quality in terms of liposomal drug concentration, encapsulation efficiency and size, and to minimize preparation variability.

Formulation Optimization of Pravastatin Loaded Long-Circulating Liposomes Using a DoE

[login to view URL] Pravastatin (PRAV) is a hydrophilic statin which has been reported to have antiangiogenic and pro-apoptotic effects. However, the beneficial effects of statins on tumour growth are obtained at high doses, usually associated with severe toxicity. Thus, site-specific delivery with liposomal systems may be a novel approach in order to enrich its therapeutic effects, while reducing the overall doses required.

Liposomal Nanoformulations as Current Tumor Targeting Approach to Cancer Therapy in Liposomes

Porfire A, Achim M, Tefas L, Sylvester B. Liposomes are drug carriers characterized by low toxicity and biocompatibility, enhancedsolubility of chemotherapeutic agents, able to encapsulate a wide range of both hydrophilic aswell as lypophilic drugs. They enhance the therapeutic index of anticancer drugs by increasingthe drug concentration in tumor cells through tumor targeting.

Direct Quantification of Meloxicam from Transdermal Therapeutic Systems by Nir Spectroscopy

[login to view URL] This study describes the development and validation of a new near infrared (NIR) spectroscopic method for the determination of meloxicam content from transdermal therapeutic systems (TTS). For this purpose, it was developed a calibration model based on an experimental design with 1 factor (meloxicam) and 5 levels (5 concentrations corresponding to 80%, 90%, 100%, 110% and 120% pharmaceutical active ingredient/TTS).

A quality by design approach for the development of lyophilized liposomes with simvastatin

[login to view URL] Lyophilization is used to ensure an increased shelf-life of liposomes, by preserving them in dry state, more stable than the aqueous dispersions. When stored as aqueous systems, the encapsulated drugs are released and the liposomes might aggregate or fuse. The aim of this study was to develop and optimize a lyophilized formulation of simvastatin loaded into long circulating liposomes using the Quality by Design (QbD) approach.

Dev. of antiprolif. LCL co-encapsulating doxorubicin and curcumin, through the use of a QbD approach

[login to view URL] The aim of this work was to use the quality-by-design (QbD) approach in the development of long-circulating liposomes co-loaded with curcumin (CUR) and doxorubicin (DOX) and to evaluate the cytotoxic potential of these liposomes in vitro using C26 murine colon carcinoma cell line.

Certifications

  • US English Level 1
    92%
  • Academic Writing
    75%

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